Patients who take or discontinue taking certain other medicines while undergoing treatment with glimepiride may experience changes in blood sugar control.
Potentiation of the blood-sugar-lowering effect and, thus, in some instances hypoglycemia may occur when one of the following medicines is taken, for example: insulin and other, oral antidiabetics, ACE inhibitors, allopurinol, anabolic steroids and male sex hormones, chloramphenicol, coumarin derivatives, cyclophosphamide, disopyramide, fenfluramine, fenyramidol, fibrates, fluoxetine, guanethidine, ifosfamide, MAO inhibitors, miconazole, para-aminosalicylic acid, quinolones, salicylates, sulfinpyrazone, sulfonamides, tetracyclines, tritoqualine, trofosfamide.
Weakening of the blood-sugar-lowering effect and, thus, raised blood sugar levels may occur when one of the following medicines is taken, for example: acetazolamine, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine and other sympathomimetic agents, glucagons, laxatives (after protracted use), nicotinic acid (in high dose). estrogens and progestogens, phenothiazines, phenytoin, rifampicin, thyroid hormones.